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| Product Name | Glucose 6-Phosphate Dehydrogenase (G6PDH) Activity Assay Kit, 60T/50S |
| Catalog No. | EATK-YJL-0013 |
| Testing Equipment | UV spectrophotometer |
| Number of Detectable Samples | 50 Samples |
| Testing Accessories | 1 mL Quartz cuvette (d=10 mm) |
| Estimated Measurement Time | 7 h (50 Samples) |
| Storage | Store according to label instructions |
| Reagents to be Prepared | None |
| Product Introduction | Glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the first and rate-limiting step of the oxidative pentose phosphate pathway (PPP). This reaction is the primary source of NADPH in most cells, which is essential for reductive biosynthesis and protecting against oxidative damage. G6PDH deficiency is the most common human enzymopathy. This kit directly measures G6PDH activity by following the formation of NADPH at 340 nm in a straightforward UV-kinetic assay, suitable for erythrocyte lysates, tissue homogenates, and cell extracts. |
| Product Application | • Diagnosis and research of G6PD deficiency and related hemolytic disorders. • Investigation of cellular redox balance, oxidative stress, and antioxidant mechanisms. • Studies on cancer metabolism, where PPP flux is often upregulated. • Research on macrophage function, inflammation, and nitric oxide synthesis. |
| Product Advantages | • Gold-Standard Method: Employs the direct, continuous kinetic assay recognized for accuracy in both research and clinical settings. • Specific for G6PDH: Includes a system to inhibit the activity of 6-phosphogluconate dehydrogenase (6PGD), ensuring measurement of only G6PDH. • Optimized for Blood Samples: Particularly suited for analysis of erythrocyte lysates, the key sample for G6PD deficiency testing. • Ready-to-Use Reagents: Pre-mixed substrates and cofactors simplify setup and improve reproducibility. |
For research use only, not for clinical use.
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