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| Product Name | Caspase-6 Colorimetric Assay Kit |
| Catalog No. | RESK-0180 |
| Description | Caspases are a family of proteases involved in apoptosis, comprising more than ten members. Caspase-6, also known as Mch-2, is generated when its precursor protein is cleaved by granzyme B to form an activated caspase-6 dimer that can induce apoptosis. Caspase-6 cleaves PARP, a key regulatory protein of apoptosis, and cleaves Lamin A, a key protein of the nuclear envelope, for which its recognition site is VEID. |
| Intended Use | For the detection of Caspase-6 activity in mammalian tissues and cells; suitable for apoptosis research and quantitative measurement of Caspase-6 enzyme activity. |
| Principle / Technology | The assay is based on the specific hydrolysis of the peptide substrate VEID-pNA (Val-Glu-Ile-Asp-p-nitroanilide) by Caspase-6. The released free p-nitroaniline (pNA) shows maximum absorbance at 405 nm, and Caspase-6 activity is determined by colorimetric measurement of pNA. |
| Detection Method | Colorimetric assay (visible spectrophotometry); absorbance read at 405 nm |
| Sample Type | Mammalian tissues and cells |
| Performance Range / Specifications | Caspase-6 activity is determined by visible-light colorimetric measurement of pNA. Suitable for the detection of Caspase-6 activity in mammalian tissues and cells. |
| Specificity | Based on the specific hydrolysis of the VEID-pNA substrate by Caspase-6. |
| Storage Conditions | Part I: store at 2-8 °C Part II: store at -25 to -15 °C |
| Shelf Life | 1 year |
| Package Specifications | 20 T 48 T 96 T |
| Expiration Date / Stability | Stable for 1 year when stored under the recommended conditions |
| Regulatory / Compliance | For research use only. |
| Recognition Site | VEID (Val-Glu-Ile-Asp); the recognition site of Caspase-6 on Lamin A is VEID |
For research use only, not for clinical use.
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