ANG I (Angiotensin I) ELISA Kit

Angiotensin I (ANG I) is a key peptide intermediate in the renin-angiotensin system (RAS), a physiological pathway critical for regulating blood pressure, fluid and electrolyte balance, and cardiovascular homeostasis. It is synthesized from angiotensinogen, a plasma protein produced by the liver, through the proteolytic action of renin—an enzyme released by the juxtaglomerular cells of the kidneys in response to reduced blood volume, low blood pressure, or sympathetic nervous system activation.
As a precursor molecule, ANG I itself has minimal biological activity but serves as the immediate substrate for angiotensin-converting enzyme (ACE), which cleaves it to form angiotensin II (ANG II)—the primary effector peptide of the RAS. ANG II exerts potent vasoconstrictive effects, stimulates aldosterone secretion from the adrenal glands, and promotes sodium and water retention, all of which contribute to increasing blood pressure and maintaining circulatory stability.
Research on ANG I is fundamental to understanding the pathogenesis of various cardiovascular and renal disorders, including hypertension, heart failure, chronic kidney disease, and metabolic syndrome. Accurate quantification of ANG I in biological samples is essential for investigating RAS activation, evaluating the efficacy of RAS-targeted therapies (such as ACE inhibitors and renin inhibitors), and exploring the role of ANG I in other physiological processes (e.g., inflammation, oxidative stress, and tissue repair).
The ANG I ELISA Kit is designed to meet the growing demand for sensitive, specific, and reliable detection of ANG I in research settings. It enables researchers to quantify ANG I in a wide range of sample types, facilitating in-depth studies on the RAS and its implications in human and animal health.