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| Product Name | Acyltransferase (AAT) Activity Assay Kit, 10T/9S, 25T/24S, 50T/48S |
| Catalog No. | FAMAK-YJL-0051 |
| Detection Method | BC2350 Visible spectrophotometry, Spectrophotometer |
| Storage | Store at -20°C, 6 months |
| Intended Use | For research use only. |
| Note | For your safety and health, please wear lab coat, disposable gloves and mask during operation. |
| Product Introduction | Acyltransferases are key enzymes that transfer acyl groups (e.g., from acyl-CoAs) to various acceptors (glycerol-3-phosphate, lysophospholipids, cholesterol, proteins), playing central roles in phospholipid synthesis, triglyceride formation, cholesterol esterification, and protein acylation. This kit provides a general, spectrophotometric method to monitor the CoA-SH released during the acyltransferase reaction using a sensitive thiol detection reagent (e.g., DTNB). |
| Product Application | • Screening and characterization of acyltransferase enzymes (GPAT, AGPAT, DGAT, LCAT, etc.). • Research on lipid biosynthesis, membrane remodeling, and lipid droplet formation. • Studies of cholesterol esterification in macrophage foam cell formation (atherosclerosis). • Drug discovery targeting metabolic disorders and cancers involving lipid metabolism. |
| Product Advantages | • Broad Application Scope: Can be adapted to measure various acyltransferase activities by providing the appropriate acyl-CoA donor and acceptor substrates, offering great experimental flexibility. • Universal Detection Principle: Detects the common product, free CoA-SH, making it applicable to a wide range of acyltransferase reactions without needing custom substrates for each enzyme. • Real-Time Kinetic Measurement: Allows continuous monitoring of enzyme activity over time, facilitating kinetic parameter determination (Km, Vmax). • Multiple Size Formats: Offered in 10T/9S, 25T/24S, and 50T/48S configurations to suit different throughput needs, from initial enzyme characterization to small-scale inhibitor screening. |
For research use only, not for clinical use.
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