Rat IL-17A ELISA Kit

Interleukin-17A (IL-17A), a key pro-inflammatory cytokine predominantly secreted by Th17 cells, plays a pivotal role in mediating immune responses and inflammatory processes—making it a critical target for research in immunology, inflammation, and related disease fields. In rodent models, particularly rat models, IL-17A has been extensively studied for its involvement in various pathological conditions, as rat physiology often exhibits closer similarities to human systems in specific inflammatory and autoimmune contexts compared to other small animal models.

Research Significance in Disease Models: Rat models are widely used to investigate autoimmune diseases such as rheumatoid arthritis (RA) and experimental autoimmune encephalomyelitis (EAE, a model for multiple sclerosis). In RA rat models, elevated IL-17A levels in synovial fluid and tissues have been linked to increased joint destruction, cartilage degradation, and recruitment of pro-inflammatory cells like neutrophils and macrophages. Similarly, in EAE models, IL-17A-producing Th17 cells accumulate in the central nervous system, exacerbating neuroinflammation and demyelination. Studying IL-17A in these rat models provides valuable insights into disease mechanisms that can inform the development of targeted therapies for human autoimmune disorders.
Role in Infectious Disease Research: Beyond autoimmune diseases, rat IL-17A is a focus in infectious disease studies. For instance, in rat models of bacterial pneumonia (e.g., caused by Streptococcus pneumoniae) or viral infections (e.g., influenza), IL-17A contributes to the recruitment of antimicrobial effector cells and the activation of mucosal immune responses. Research has shown that IL-17A deficiency in rats can lead to impaired clearance of pathogens and increased susceptibility to severe infection, highlighting its role in host defense. Accurate detection of rat IL-17A is therefore essential for evaluating immune responses to pathogens in preclinical studies.
Demand for Reliable Detection Tools: As the use of rat models in IL-17A-related research continues to grow, there is an increasing need for sensitive, specific, and user-friendly detection kits. Traditional methods for cytokine detection, such as Western blotting or flow cytometry, often require large sample volumes, complex sample processing, or specialized equipment. ELISA kits, by contrast, offer a high-throughput, cost-effective, and straightforward solution—enabling researchers to quantify IL-17A levels in various rat sample types (e.g., serum, plasma, cell culture supernatants, tissue homogenates) with minimal technical barriers. The Rat IL-17A ELISA Kit (Cat.No: EC-0026) is designed to meet this demand, providing a robust tool for consistent and accurate IL-17A measurement in preclinical research settings.