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| Product Name | PML-RARα L Gene Quantification Kit (Fluorescent PCR Method) |
| Catalog No. | BDDK-HMM-0025 |
| Description | Acute promyelocytic leukemia (APL) is a specific type of acute myeloid leukemia (AML-M3 type), and the vast majority of patients have a specific chromosomal translocation t(15;17)(q22;q12), which forms the PML-RARα fusion gene, and the protein product of which leads to blockage of cellular differentiation and insufficient apoptosis, which are the main molecular mechanisms of APL development. The PML-RARα fusion gene is heterogeneous, and PML gene recombination occurs at different regions of breakpoint concentration, resulting in three isoforms, one in which PML Exon6 and RARα Exon3 exons combine to form an L-type fusion gene (bcr1), a second in which PML Exon6 and RARα Exon3 exons combine to form a V-type fusion gene (bcr2) and the third PML Exon6 and RARα Exon3 exon combine to form an S-type fusion gene (bcr3).The PML-RARα fusion gene has a high correlation with AML-M3 type, and the results of this fusion gene test are helpful in the diagnosis of AML-M3 type. |
| Disease Type | Leukaemia |
| Applications | This test kit quantifies PML-RARα fusion gene type L (bcr1) by fluorescence quantitative PCR. |
| Sample Type | Peripheral blood |
| Detection Methods | Fluorescent PCR Method |
| Storage | -20°C |
For research use only, not for clinical use.
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