Murine IL-1 alpha ELISA Kit

Discovery and Significance: Interleukin-1 alpha (IL-1α), also known as hematopoietin-1, is a crucial cytokine in the immune system. It was first discovered in the 1970s and has since been extensively studied for its role in inflammation and immune responses. IL-1α is produced by various cell types, including macrophages, monocytes, and dendritic cells, and it plays a vital role in initiating and regulating the inflammatory response.

Biological Functions: IL-1α is involved in a wide range of biological processes. It stimulates the production of other cytokines, such as IL-6 and TNF-α, and promotes the differentiation and activation of T cells and B cells. Additionally, IL-1α is essential for the regulation of fever, acute-phase protein synthesis, and the induction of apoptosis in certain cell types. Its actions are mediated through binding to specific receptors on the cell surface, leading to intracellular signaling cascades.

Research Applications: The study of IL-1α has significant implications for understanding and treating various diseases. Elevated levels of IL-1α are often observed in inflammatory and autoimmune conditions, such as rheumatoid arthritis, inflammatory bowel disease, and certain cancers. Researchers use IL-1α ELISA kits to measure its concentration in biological samples, providing valuable insights into disease mechanisms and potential therapeutic targets.