Perforin, also known as PFP or PRF1, is a pore-forming protein released by cytotoxic lymphocytes such as cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It plays a crucial role in the immune system by forming pores in the membranes of target cells, leading to cell lysis and death. This mechanism is essential for the immune response against infected or cancerous cells. The discovery of perforin dates back to the 1980s when researchers began to understand its function in cell-mediated cytotoxicity. Since then, it has been a key area of study in immunology, oncology, and infectious diseases. Understanding perforin's role helps in developing therapeutic strategies for various diseases, including cancer and autoimmune disorders.
High Specificity: This kit is designed to specifically recognize natural human perforin, ensuring accurate detection without cross-reactivity with other related proteins such as Trail, Trail R3, Trail R4, Granzyme B, TNF, IFN, Fas, Fas L, IL-1b, and IL-2.
Immediate Detection: It allows for immediate in vitro detection of human perforin, providing quick results that are essential for timely diagnosis and research.
Convenient Storage: The kit can be stored at 4°C, making it easy to maintain its stability and usability without requiring specialized storage conditions.
Room Temperature Transportation: The ability to transport the kit at room temperature ensures ease of handling and reduces logistical challenges, making it accessible for a wide range of users.
Reliable Detection: The kit's high specificity ensures reliable detection of human perforin, providing trustworthy results for both research and diagnostic purposes.
User-Friendly: With straightforward storage and transportation conditions, this kit is easy to use and manage, even for laboratories with varying levels of resources.
Time-Efficient: Immediate detection capabilities save valuable time, allowing researchers and clinicians to proceed with their work more efficiently.
Versatile Applications: Suitable for a range of applications, including basic research, clinical diagnostics, and drug development studies related to perforin and its role in various diseases.