Human IL-8 ELISA kit

Discovery and Naming: Interleukin-8 (IL-8), also known as CXCL8, is a member of the CXC chemokine family. It was first discovered in the early 1980s and has since been extensively studied for its role in the immune response. The name "Interleukin-8" reflects its ability to interact between leukocytes, while "CXCL8" highlights its structural characteristics as a CXC chemokine with an ELR motif, which is crucial for its neutrophil-activating properties.

Biological Role: IL-8 is primarily produced by macrophages, monocytes, and endothelial cells in response to various inflammatory stimuli. It plays a pivotal role in the recruitment and activation of neutrophils and T-cells, making it a key player in the innate immune response. Additionally, IL-8 has been implicated in various pathological conditions, including chronic inflammation, autoimmune diseases, and cancer progression, where it contributes to angiogenesis and tumor growth.

Research Significance: The study of IL-8 has gained significant attention in the fields of immunology, oncology, and pharmacology. Researchers are particularly interested in understanding its signaling pathways and the mechanisms through which it modulates immune cell functions. This knowledge is crucial for the development of therapeutic strategies targeting IL-8, such as neutralizing antibodies and small molecule inhibitors, which hold promise for treating a wide range of inflammatory and immune-related disorders.