Human IL-4 HS ELISA Kit

Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1 (BCSF-1) or T-cell replacement factor (TCRF), is a multifunctional cytokine that plays a crucial role in the immune system. It is primarily produced by T-helper 2 (Th2) cells, mast cells, and basophils.

IL-4 is involved in a variety of biological processes. It promotes the differentiation and proliferation of B cells, enhances the expression of class II major histocompatibility complex (MHC) molecules on B cells, and stimulates immunoglobulin (Ig) class switching to IgG4 and IgE in humans.

In addition to its effects on B cells, IL-4 also acts on other immune cells. It inhibits the production of pro-inflammatory cytokines by macrophages and dendritic cells, and it promotes the development of Th2 immune responses by stimulating the production of other Th2-associated cytokines such as IL-5 and IL-13.

The discovery of IL-4 dates back to the 1980s when researchers identified a factor that could replace the need for T cells in the proliferation of B cells. Since then, extensive research has been conducted to elucidate its structure, function, and role in various diseases.

IL-4 has been implicated in several pathological conditions, including allergic diseases such as asthma and atopic dermatitis, autoimmune diseases, and certain types of cancer. Understanding the levels of IL-4 in biological samples can provide valuable insights into the underlying immune responses and help in the diagnosis and treatment of these conditions.