Human IL-12p70 HS ELISA Kit

Discovery and Significance: Interleukin-12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric cytokine that plays a crucial role in the regulation of immune responses. IL-12p70, the biologically active form of IL-12, is composed of a p40 subunit and a p35 subunit. It was first identified in the early 1990s and has since been extensively studied for its potent effects on the differentiation and proliferation of T cells and natural killer (NK) cells.

Biological Functions: IL-12p70 is a key player in the immune system. It promotes the differentiation of naive T cells into Th1 cells, which are essential for cell-mediated immunity against intracellular pathogens such as viruses and certain bacteria. Additionally, IL-12p70 enhances the cytotoxic activity of NK cells and stimulates the production of interferon-gamma (IFN-γ), a critical cytokine for immune defense.

Research and Applications: The study of IL-12p70 has significant implications in various fields of medical research. It is involved in autoimmune diseases, cancer immunotherapy, and vaccine development. Researchers use IL-12p70 as a biomarker to understand disease progression and to evaluate the efficacy of therapeutic interventions. The development of high-sensitivity (HS) ELISA kits for IL-12p70 detection has become increasingly important to accurately measure its levels in biological samples.