Human IL-10 ELISA kit

Interleukin-10 (IL-10), a key pleiotropic cytokine, plays a pivotal role in regulating the immune system’s balance between pro-inflammatory and anti-inflammatory responses. Discovered in the early 1990s, it was initially identified as a "cytokine synthesis inhibitory factor" due to its ability to suppress the production of pro-inflammatory cytokines like TNF-α, IFN-γ, and IL-6 by activated T cells and macrophages. Over decades of research, its multifaceted functions have been extensively studied, making it a critical target in both basic immunology research and clinical diagnostics.

In the context of human health, IL-10 levels are closely associated with a wide range of physiological and pathological conditions. For instance:
In infectious diseases: During bacterial or viral infections (such as influenza, COVID-19, or bacterial sepsis), IL-10 is often secreted as a protective mechanism to limit excessive inflammation that could damage host tissues. Abnormal IL-10 expression—either too low (leading to hyperinflammation) or too high (contributing to immune suppression and increased pathogen persistence)—is linked to worse disease outcomes.
In autoimmune and inflammatory disorders: Conditions like rheumatoid arthritis, inflammatory bowel disease (IBD), and psoriasis are characterized by dysregulated immune responses. Measuring IL-10 levels helps researchers and clinicians assess the severity of inflammation, monitor disease progression, and evaluate the efficacy of anti-inflammatory therapies. For example, in IBD patients, reduced IL-10 production by regulatory T cells is associated with more severe intestinal inflammation.
In cancer research: IL-10 exhibits dual roles in cancer. While it can inhibit anti-tumor immune responses (by suppressing cytotoxic T cell activity) and promote tumor growth in some solid tumors (e.g., colorectal cancer, melanoma), it also shows anti-tumor effects in certain hematological malignancies. Accurate detection of IL-10 is therefore essential for understanding tumor microenvironment dynamics and developing targeted immunotherapies.

Against this backdrop, reliable and sensitive tools for detecting human IL-10 are in high demand across academic research laboratories, pharmaceutical companies, and clinical diagnostic facilities. The Human IL-10 ELISA Kit (Cat.No: EC-0080) from Alta Diagno Tech is designed to meet this need, leveraging the enzyme-linked immunosorbent assay (ELISA) technique—one of the most widely used methods for cytokine detection due to its high specificity, reproducibility, and ease of use. ELISA kits eliminate the need for complex equipment (e.g., flow cytometers) and allow for high-throughput analysis, making them accessible to a broad range of users, from small research labs to large-scale diagnostic centers.