| Product Name | Human CD141 ELISA Kit |
| Catalog No. | EC-0050 |
| Description | Human CD141 ELISA kit is a kit for the in vitro detection of human CD141 protein using enzyme-linked adsorption reaction. |
| Species Characteristics | Human |
| Cross-reaction | No cross reactivity with other human soluble molecules. |
| Specificity | Recognizes both natural and recombinant human soluble thrombomodulin. |
| Application | It can be used for immediate in vitro detection of human CD141. |
| Storage | Store at 4°C. |
| Transportation Condition | Transportation at room temperature. |
Human CD141, also known as Thrombomodulin (TM), is a crucial protein that plays a significant role in the regulation of blood coagulation and inflammation. It is primarily expressed on the surface of endothelial cells and serves as a cofactor for the activation of protein C by thrombin. This activation is essential for the anticoagulant and anti-inflammatory pathways.
Discovery and Research History: Thrombomodulin was first identified in the 1980s. Since then, extensive research has shown its importance in maintaining vascular homeostasis. It has been studied in various pathological conditions, including sepsis, thrombosis, and inflammatory diseases.
Biological Functions:
Anticoagulant Activity: By binding to thrombin, it converts protein C into activated protein C (APC), which in turn inhibits the coagulation cascade.
Anti-inflammatory Effects: APC also possesses anti-inflammatory properties, protecting endothelial cells from damage.
Role in Angiogenesis: Thrombomodulin is involved in the regulation of blood vessel formation and remodeling.
Clinical Significance: Elevated levels of soluble thrombomodulin (sTM) in the blood are often associated with endothelial dysfunction and can be used as a biomarker for various diseases, such as sepsis, acute respiratory distress syndrome (ARDS), and cardiovascular diseases.
High Sensitivity: The Human CD141 ELISA Kit is designed to detect low levels of human CD141 protein with high precision.
Specificity: It recognizes both natural and recombinant human soluble thrombomodulin, ensuring accurate measurements.
No Cross-Reactivity: The kit does not cross-react with other human soluble molecules, providing reliable results.
Convenient Storage: It can be stored at 4°C, making it easy to handle and maintain.
Room Temperature Transportation: The kit can be transported at room temperature without compromising its quality.
Accurate Detection: The kit's ability to accurately detect human CD141 protein makes it a reliable tool for research and clinical applications.
Wide Application Range: It can be used for immediate in vitro detection of human CD141, suitable for various studies related to blood coagulation, inflammation, and endothelial function.
User-Friendly: The kit is easy to use, with clear instructions and straightforward procedures, making it accessible to researchers and clinicians alike.
Cost-Effective: The kit offers a cost-effective solution for detecting human CD141, providing high-quality results without the need for expensive equipment.
Quality Assurance: The kit has undergone rigorous testing to ensure its reliability and consistency, providing users with confidence in their results.
For in vitro diagnostic use.
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