Human CD130 ELISA Kit

Introduction to CD130: CD130, also known as Glycoprotein 130 (gp130), is a crucial receptor protein that plays a significant role in the immune system. It is a member of the interleukin-6 receptor family and is widely expressed on the surface of various immune cells, such as T cells, B cells, and macrophages. CD130 is involved in the signaling pathways of multiple cytokines, including interleukin-6 (IL-6), interleukin-11 (IL-11), and leukemia inhibitory factor (LIF), and is essential for the regulation of immune responses, cell differentiation, and proliferation.

Discovery and Research History: The discovery of CD130 dates back to the early 1990s when researchers were investigating the mechanisms of cytokine signaling. Since then, extensive research has been conducted to elucidate its structure, function, and involvement in various biological processes. Studies have shown that CD130 is a transmembrane protein with a large extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain is responsible for binding to cytokines, while the intracellular domain contains signaling motifs that initiate downstream signaling cascades.

Clinical Significance: Abnormal expression or function of CD130 has been implicated in several diseases. In cancer, the overexpression of CD130 is often observed in tumor cells and is associated with tumor progression, metastasis, and resistance to therapy. In autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, dysregulation of CD130 signaling contributes to chronic inflammation and tissue damage. Therefore, CD130 has become an important target for therapeutic interventions and diagnostic biomarker development.