Introduction
The Human CD117 ELISA Kit is designed to detect the human CD117 protein, also known as c-kit. CD117 is a receptor tyrosine kinase that plays a crucial role in the development and function of various cell types, including hematopoietic cells, melanocytes, and germ cells.
It is involved in cell proliferation, differentiation, and survival. The c-kit ligand, also known as stem cell factor (SCF), binds to CD117 and activates downstream signaling pathways that regulate these cellular processes.
Abnormal expression of CD117 has been associated with several diseases, such as certain types of cancer and hematological disorders. Therefore, the detection and quantification of CD117 are important for research and diagnostic purposes.
Aliases
The human CD117 protein is also referred to as c-kit, CD117 antigen, and proto-oncogene c-kit. These names reflect its various functions and characteristics in different biological contexts.
Research Significance
In cancer research, CD117 is a valuable biomarker for the diagnosis and prognosis of certain malignancies. For example, in gastrointestinal stromal tumors (GISTs), the overexpression of CD117 is a key feature and a target for therapeutic interventions.
In the field of stem cell research, CD117 is used as a marker to identify and isolate hematopoietic stem cells. This is essential for understanding the mechanisms of blood cell formation and for developing stem cell-based therapies.
High Sensitivity
The kit is designed to detect low levels of human CD117 protein with high accuracy and precision.
Specificity
It specifically recognizes both natural and recombinant human soluble c-kit, ensuring reliable results.
No Cross-Reactivity
The kit does not cross-react with other human soluble receptors, providing accurate detection of CD117 without interference.
Convenient Storage and Transportation
The kit can be stored at 4°C and transported at room temperature, making it easy to handle and use.
Reliable Detection
The Human CD117 ELISA Kit offers a reliable method for detecting human CD117 protein, providing consistent and accurate results.
Wide Range of Applications
It can be used for a variety of applications, including basic research, clinical diagnostics, and drug development.
User-Friendly
The kit is easy to use, with a straightforward protocol that can be followed by researchers and technicians with minimal training.
Cost-Effective
The kit provides an efficient and cost-effective solution for the detection of human CD117 protein, making it accessible to a wide range of laboratories and research institutions.