Human CD102 ELISA Kit

CD102, also known as intercellular adhesion molecule-2 (ICAM-2), is a key member of the immunoglobulin superfamily (IgSF) of adhesion molecules, playing indispensable roles in multiple physiological and pathological processes.

Physiological and Pathological Significance
Immune Response Regulation: CD102 is predominantly expressed on the surface of vascular endothelial cells, lymphocytes, monocytes, and dendritic cells. It mediates cell-cell adhesion by binding to its ligands, such as lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18) and macrophage-1 antigen (Mac-1, CD11b/CD18). This adhesion process is critical for the recruitment of immune cells to sites of inflammation or infection—for instance, during acute inflammation, endothelial cell-expressed CD102 interacts with LFA-1 on circulating T cells, facilitating T cell rolling, firm adhesion, and subsequent transmigration across the vascular endothelium to eliminate pathogens.
Vascular Homeostasis Maintenance: In normal vascular tissues, CD102 contributes to maintaining the integrity and stability of the vascular barrier. It participates in the regulation of endothelial cell junction formation and vascular permeability, preventing abnormal leakage of vascular contents. Dysfunction of CD102 has been associated with increased vascular permeability in diseases like sepsis, where excessive inflammation disrupts CD102-mediated endothelial adhesion, leading to tissue edema and organ damage.
Link to Disease Progression: Accumulating research has highlighted the involvement of CD102 in various diseases. In cancer, for example, tumor-associated endothelial cells may upregulate CD102 expression to promote the adhesion and extravasation of tumor cells, facilitating cancer metastasis. In autoimmune diseases such as rheumatoid arthritis, abnormal activation of immune cells driven by CD102-LFA-1 interactions exacerbates joint inflammation and tissue destruction. Additionally, CD102 has been implicated in the pathogenesis of cardiovascular diseases, including atherosclerosis, where it modulates the recruitment of monocytes to atherosclerotic plaques.

Demand for CD102 Detection
Given the pivotal role of CD102 in immunity, vascular biology, and disease, accurate and sensitive detection of CD102 protein levels is essential for both basic research and clinical translational studies. Researchers rely on reliable detection tools to:
Investigate the expression patterns of CD102 in different tissues, cell types, and disease models;
Explore the molecular mechanisms underlying CD102-mediated cellular processes (e.g., immune cell recruitment, tumor metastasis);
Evaluate the efficacy of therapeutic agents targeting CD102 or its ligands (e.g., monoclonal antibodies against CD102) in preclinical studies;
Develop potential diagnostic biomarkers for diseases associated with abnormal CD102 expression.

The Human CD102 ELISA Kit (Cat.No: EC-0039) is specifically designed to meet these demands, providing a robust in vitro assay for quantitative detection of human CD102 protein.