Human CD178 ELISA Kit

Human CD178, also known as Fas Ligand (FasL) or CD95 Ligand, is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death. It is primarily expressed on the surface of immune cells such as T cells and natural killer (NK) cells.

Discovery and Research History: Fas Ligand was first identified in the early 1990s. Since then, extensive research has shown its importance in maintaining immune homeostasis by inducing apoptosis in target cells. It has been studied in various pathological conditions, including autoimmune diseases, cancer, and viral infections.

Biological Functions:
Induction of Apoptosis: Fas Ligand binds to its receptor, Fas (CD95), on target cells, triggering the extrinsic apoptotic pathway.
Immune Regulation: It helps regulate immune responses by eliminating activated T cells and other immune cells after their job is done.
Role in Cancer: Abnormal expression of Fas Ligand has been observed in various cancers, where it can either promote or inhibit tumor growth depending on the context.

Clinical Significance: Elevated levels of soluble Fas Ligand (sFasL) in the blood are often associated with autoimmune diseases and certain cancers. It can be used as a biomarker for disease progression and therapeutic response.